Impact of Pistacia lentiscus Plant Gum on Particle Size and Swelling Index in Central Composite Designed Amoxycillin Trihydrate Mucoadhesive Microspheres

Abstract: Objectives: The ambition of this study is to find the mucoadhesive assets Pistacia lentiscus plant gum (mastic gum) by combining it into microspheres with Amoxicillin Trihydrate (ATH). Significance: Due its short stomach residence duration, ATH efficient against H. pylori but can be improved creating Mucoadhesive Microspheres (MMS) that keep trihydrate in stomach. In study, has been exposed have gastroprotective and eradication possessions inclusion being able increase mucoadhesion. Methods Results: was performed influence mucilage amount on particle size swelling index. MMS (9 batches) were made carbopol 934P (C-934P) changeable extents commonly called Mastic Gum (MG). A central composite design factors (MG C-934 P levels) index as an output. batches evaluated for their physical limitations, level, liberation part amiability research. seen 35.2±0.3-48.1±0.6μm. batch B-1, smallest compared larger B-8. overall formula +47.04+0.6500A+1.93B-0.1750AB-0.6167A²-8.47B². ranged from 58.6±1.3-74.3±1.6 also observed polymer level +54.21+1.40A+6.25B+0.4750AB-0.5667A²+2.78B². Conclusion: search establishes depend levels. investigation revealed consistently released a regulated pattern encapsulation efficiency, mucosal adhesion, content, other limitations considered good. When prepared MMS, achieve good gastric-specific drug delivery when enriched MG C-934P. had smooth surfaces found spherical scanning electron microscopy. Keywords: gum, Microspheres, Mucoadhesive, Particle size.